5-Amino-1mq ⎮ 5mg

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor. NNMT is highly expressed in adipose tissue and plays a role in regulating cellular methylation capacity and NAD+ precursor availability.

Preclinical research has investigated 5-Amino-1MQ in the context of adipogenesis inhibition, metabolic reprogramming in adipocytes, and its effects on the SAM/SAH ratio and one-carbon metabolism. Studies have also examined its influence on body composition parameters, energy expenditure, and SIRT1 activity in rodent models of diet-induced obesity.

CAS Number: 1370261-97-4 | Molecular Formula: C₁₀H₁₁N₂⁺ (as iodide salt) | Purity: ≥98%

⚠️ Important Notice: Research Use Only ⚠️ This product is strictly for research purposes and is not intended for human or animal consumption. Store properly and ensure legal compliance.